Answer:

In in vitro fertilization (IVF), embryos must be cultured in an environment with strictly controlled conditions, including temperature, pressure, and gas concentration, before being transferred to the uterus.

With traditional embryo culture methods, embryologists periodically remove embryos for microscopic observation and quality assessment. Embryos are primarily evaluated based on morphological characteristics such as the number and size of blastomeres, and the degree of cell fragmentation. This process can alter the culture environment and affect embryo development.

With the Time-lapse system integrated with artificial intelligence (AI), embryos are continuously monitored throughout the culture process by an internal camera, eliminating the need to remove them for assessment. This maintains a stable culture environment for the embryos. In addition to embryo morphology, the Time-lapse system records each division time of the embryo and identifies certain abnormal cell division patterns, such as direct division or reverse division.

The Time-lapse embryo culture system features continuous camera observation and integrated artificial intelligence (AI). Photo: IVF Tam Anh

The Time-lapse embryo culture system features continuous camera observation and integrated artificial intelligence (AI). Photo: IVF Tam Anh

By analyzing embryo data, AI helps assign scores to embryos at various developmental stages, predicting their future developmental potential. This serves as an additional criterion, assisting doctors and embryologists in evaluating and prioritizing embryos with better developmental potential and implantation rates for transfer consideration.

However, AI cannot replace embryologists, nor can it confirm an embryo is genetically normal. If a patient has an indication for assessing chromosomal abnormalities or genetic diseases, the doctor will advise on appropriate preimplantation genetic testing (PGT). After genetic results are available, combining them with AI scores helps strengthen embryo selection, optimizing the chance of pregnancy for the patient.

Good embryo quality also depends on age, egg and sperm quality, genetic factors, and other elements. After embryo formation, the ability to implant is also related to the uterine lining and the woman's reproductive health status.

At IVF Tam Anh, approximately 95% of patients undergo embryo culture using the AI-integrated Time-lapse system. This system is one link in the IVF process, supporting doctors and embryologists in decision-making, rather than being the sole determinant of success.

Master of Science Le Thi Thu Thao

Deputy Lab Manager, Center for Reproductive Assistance

Tam Anh General Hospital TP HCM