There is no scientific evidence to suggest that antidepressants damage the brain. On the contrary, many studies show that untreated depression is the factor that causes brain damage.

Prolonged depression is associated with reduced hippocampal volume, impaired prefrontal cortex function, disrupted brain network connectivity, and declines in memory, attention, and processing speed. Antidepressant medication helps improve these changes, rather than destroying them.

Antidepressants can have side effects, such as drowsiness, initial sluggishness, dry mouth, and nausea. However, these are temporary and distinct from "brain damage." Side effects often diminish as the brain adapts, and can be managed by adjusting the dosage or changing medication. These medications do not offer immediate relief; users typically need at least two weeks to experience their full effects. Starting with a low dose and close monitoring during the initial days are key to minimizing side effects.

Antidepressants have been used for over 60 years by hundreds of millions of patients globally, supported by rigorous long-term research and monitoring systems. If these medications "damaged the brain," they would have been withdrawn from the market. Many patients, influenced by false information, fear treatment and stop taking their medication on their own, leading to prolonged and more severe depression, increasing the risk of relapse and suicide. Patients must adhere to the treatment protocols prescribed by specialist doctors to avoid financial loss and prolonged suffering.

Depression is a common mental illness characterized by intense and recurring feelings of sadness and hopelessness; a loss of interest in previously enjoyed activities; isolation from relationships; constant self-criticism; frustration and irritability over minor setbacks; a lack of energy; and a persistent feeling of emptiness even when performing normal daily tasks.

Doctor Nguyen Viet Chung

Department of Mental Health, E Hospital