Preimplantation genetic testing for aneuploidy (PGT-A) does not reduce embryo quality if performed using the correct technique. This test detects chromosomal abnormalities in embryos, helping doctors select high-quality embryos before uterine transfer. This process reduces the risk of failed embryo transfer or miscarriage.

PGT-A is performed when the embryo reaches the blastocyst stage, typically on day 5 or 6. At this stage, the embryo has differentiated into an inner cell mass, which develops into the fetus, and a trophectoderm layer, which primarily forms the placenta. An embryologist takes a small number of cells from the trophectoderm layer for testing, minimizing impact on the inner cell mass.

An embryologist performs embryo screening. Illustration: IVF Tam Anh

Embryos are sensitive to environmental changes. Therefore, post-biopsy results depend on the sampling technique, freezing-thawing process, and culture conditions. Strict control of the laboratory environment is crucial throughout the entire screening process.

At the Center for Reproductive Assistance, Tam Anh General Hospital (IVF Tam Anh), all procedures are carried out in an ultra-clean laboratory environment adhering to ISO 6 and ISO 5 standards, minimizing impact on the embryos. After biopsy, embryos are cryopreserved using vitrification and stored in liquid nitrogen at approximately -196 degrees C while awaiting results. Once PGT-A results are available, doctors counsel on the chromosomal status of each embryo. The highest quality embryos are selected for uterine transfer.

PGT-A is not a mandatory indication for all IVF cases. Doctors assess and individualize treatment strategies based on the wife's age, cause of infertility, treatment history, ovarian reserve, sperm and oocyte quality, and other related factors. This allows them to recommend the most suitable treatment, optimizing the chance of pregnancy for each patient.

ThS Le Thi Thu Thao

Deputy Lab, Center for Reproductive Assistance

Tam Anh General Hospital TP HCM